Yes.  You need administrative rights to install and run EnFuzion3D on the Control Root Computer and the Compute Nodes.  You also need administrative rights to install EnFuzion3D on User Submit Computers, but artists will not need administrative rights to run EnFuzion3D on their workstations after it is installed.   

Axceleon provides very detailed descriptions on this topic in the EnFuzion3D Installation Guide.  Please consult the product documentation for full details.